Inhibitory effects of marine-derived DNA-binding anti-tumour tetrahydroisoquinolines on the Fanconi anaemia pathway

BACKGROUND AND PURPOSE: We have previously shown that cells with a defective Fanconi anaemia (FA) pathway are hypersensitive to trabectedin, a DNA-binding anti-cancer tetrahydroisoquinoline (DBAT) whose adducts functionally mimic a DNA inter-strand cross link (ICL). Here we expand these observations...

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Detalhes bibliográficos
Main Authors: Martínez, Sandra, Pérez, Laura, Galmarini, Carlos M, Aracil, Miguel, Tercero, Juan C, Gago, Federico, Albella, Beatriz, Bueren, Juan A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799600/
https://ncbi.nlm.nih.gov/pubmed/23937566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12331
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