Simvastatin induces a central hypotensive effect via Ras-mediated signalling to cause eNOS up-regulation

BACKGROUND AND PURPOSE: Clinical studies indicate that statins have a BP-lowering effect in hypercholesterolemic individuals with hypertension. Specifically, statins modulate BP through the up-regulation of endothelial NOS (eNOS) activation in the brain. However, the signalling mechanisms through wh...

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Detalhes bibliográficos
Principais autores: Cheng, Wen-Han, Ho, Wen-Yu, Chang, Chien-Feng, Lu, Pei-Jung, Cheng, Pei-Wen, Yeh, Tung-Chen, Hong, Ling-Zong, Sun, Gwo-Ching, Hsiao, Michael, Tseng, Ching-Jiunn
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799598/
https://ncbi.nlm.nih.gov/pubmed/23889671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12317
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