Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation

Increased CCL2 expression in prostate cancer (PCa) cells enhanced metastasis via macrophage recruitment. However, its linkage to androgen receptor (AR)-mediated PCa progression remains unclear. Here, we identified a previously unrecognized regulation: targeting AR with siRNA in PCa cells increased m...

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Bibliografske podrobnosti
Main Authors: Izumi, Kouji, Fang, Lei-Ya, Mizokami, Atsushi, Namiki, Mikio, Li, Lei, Lin, Wen-Jye, Chang, Chawnshang
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2013
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799493/
https://ncbi.nlm.nih.gov/pubmed/23982944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202367
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