Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia

FLT3-ITD mutations are prevalent mutations in acute myeloid leukaemia (AML). PRL-3, a metastasis-associated phosphatase, is a downstream target of FLT3-ITD. This study investigates the regulation and function of PRL-3 in leukaemia cell lines and AML patients associated with FLT3-ITD mutations. PRL-3...

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Hlavní autoři: Park, Jung Eun, Yuen, Hiu Fung, Zhou, Jian Biao, Al-aidaroos, Abdul Qader O, Guo, Ke, Valk, Peter J, Zhang, Shu Dong, Chng, Wee Joo, Hong, Cheng William, Mills, Ken, Zeng, Qi
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799491/
https://ncbi.nlm.nih.gov/pubmed/23929599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202183
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