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Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms
Reflex vasoconstriction is attenuated in aged skin due to a functional loss of adrenergic vasoconstriction. Bioavailability of tetrahydrobiopterin (BH(4)), an essential cofactor for catecholamine synthesis, is reduced with aging. Locally administered BH(4) increases vasoconstriction through adrenerg...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798824/ https://ncbi.nlm.nih.gov/pubmed/23869061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00626.2013 |
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