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Oral sapropterin acutely augments reflex vasodilation in aged human skin through nitric oxide-dependent mechanisms
Functional constitutive nitric oxide synthase (NOS) and its cofactor tetrahydrobiopterin (BH(4)) are required for full reflex cutaneous vasodilation and are attenuated in primary aging. Acute, locally administered BH(4) increases reflex vasodilation through NO-dependent mechanisms in aged skin. We h...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798819/ https://ncbi.nlm.nih.gov/pubmed/23743404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00481.2013 |
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