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Oral sapropterin acutely augments reflex vasodilation in aged human skin through nitric oxide-dependent mechanisms
Functional constitutive nitric oxide synthase (NOS) and its cofactor tetrahydrobiopterin (BH(4)) are required for full reflex cutaneous vasodilation and are attenuated in primary aging. Acute, locally administered BH(4) increases reflex vasodilation through NO-dependent mechanisms in aged skin. We h...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798819/ https://ncbi.nlm.nih.gov/pubmed/23743404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00481.2013 |
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