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Molecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANA
LANA is the KSHV-encoded terminal repeat binding protein essential for viral replication and episome maintenance during latency. We have determined the X-ray crystal structure of LANA C-terminal DNA binding domain (LANA(DBD)) to reveal its capacity to form a decameric ring with an exterior DNA bindi...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798644/ https://ncbi.nlm.nih.gov/pubmed/24146617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003672 |
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