Identification of Cysteine Residues in Human Cationic Amino Acid Transporter hCAT-2A That Are Targets for Inhibition by N-Ethylmaleimide

In most cells, cationic amino acids such as l-arginine, l-lysine, and l-ornithine are transported by cationic (CAT) and y(+)L (y(+)LAT) amino acid transporters. In human erythrocytes, the cysteine-modifying agent N-ethylmaleimide (NEM) has been shown to inhibit system y(+) (most likely CAT-1), but n...

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Bibliographische Detailangaben
Hauptverfasser: Beyer, Sarah R., Mallmann, Robert T., Jaenecke, Isabel, Habermeier, Alice, Boissel, Jean-Paul, Closs, Ellen I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Membrane Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798505/
https://ncbi.nlm.nih.gov/pubmed/24019517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.490698
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