Critical Role of AKT Protein in Myeloma-induced Osteoclast Formation and Osteolysis

Abnormal osteoclast formation and osteolysis are the hallmarks of multiple myeloma (MM) bone disease, yet the underlying molecular mechanisms are incompletely understood. Here, we show that the AKT pathway was up-regulated in primary bone marrow monocytes (BMM) from patients with MM, which resulted...

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Detalhes bibliográficos
Main Authors: Cao, Huiling, Zhu, Ke, Qiu, Lugui, Li, Shuai, Niu, Hanjie, Hao, Mu, Yang, Shengyong, Zhao, Zhongfang, Lai, Yumei, Anderson, Judith L., Fan, Jie, Im, Hee-Jeong, Chen, Di, Roodman, G. David, Xiao, Guozhi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798504/
https://ncbi.nlm.nih.gov/pubmed/24005670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.469973
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