Steap4 Plays a Critical Role in Osteoclastogenesis in Vitro by Regulating Cellular Iron/Reactive Oxygen Species (ROS) Levels and cAMP Response Element-binding Protein (CREB) Activation

Iron is essential for osteoclast differentiation, and iron overload in a variety of hematologic diseases is associated with excessive bone resorption. Iron uptake by osteoclast precursors via the transferrin cycle increases mitochondrial biogenesis, reactive oxygen species production, and activation...

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Bibliographic Details
Main Authors: Zhou, Jian, Ye, Shiqiao, Fujiwara, Toshifumi, Manolagas, Stavros C., Zhao, Haibo
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798475/
https://ncbi.nlm.nih.gov/pubmed/23990467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.478750
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