Inhibition of Glycogen Synthase Kinase-3β Prevents Remifentanil-Induced Hyperalgesia via Regulating the Expression and Function of Spinal N-Methyl-D-Aspartate Receptors In Vivo and Vitro

A large number of experimental and clinical studies have confirmed that brief remifentanil exposure can enhance pain sensitivity presenting as opioid-induced hyperalgesia (OIH). N-methyl-D-aspartate (NMDA) receptor antagonists have been reported to inhibit morphine analgesic tolerance in many studie...

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Autores principales: Li, Yize, Wang, Haiyun, Xie, Keliang, Wang, Chunyan, Yang, Zhuo, Yu, Yonghao, Wang, Guolin
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797695/
https://ncbi.nlm.nih.gov/pubmed/24147079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077790
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