Enhancement of spinal dorsal horn neuron N-methyl-D-aspartate receptor phosphorylation as the mechanism of remifentanil-induced hyperalgesia: Roles of protein kinase C and calcium/calmodulin-dependent protein kinase II

BACKGROUND: Modulation of N-methyl-D-aspartate receptor subunits NR1 and NR2 through phosphorylation mediates opioid-induced hyperalgesia, and activations of protein kinase C and extracellular signal-regulated kinase 1/2 potentiate while activation of calcium/calmodulin-dependent protein kinase II i...

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Detalhes bibliográficos
Publicado no:Mol Pain
Main Authors: Li, Sisi, Zeng, Jie, Wan, Xiaoxiao, Yao, Ying, Wu, Yujia, Zhao, Nan, Yu, Cong, Xia, Zhengyuan
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549877/
https://ncbi.nlm.nih.gov/pubmed/28714352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806917723789
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