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Molecular Dynamics Simulations of Scorpion Toxin Recognition by the Ca(2+)-Activated Potassium Channel K(Ca)3.1
The Ca(2+)-activated channel of intermediate-conductance (K(Ca)3.1) is a target for antisickling and immunosuppressant agents. Many small peptides isolated from animal venoms inhibit K(Ca)3.1 with nanomolar affinities and are promising drug scaffolds. Although the inhibitory effect of peptide toxins...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Biophysical Society
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3797572/ https://ncbi.nlm.nih.gov/pubmed/24138859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.08.046 |
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