Optimization of routine KRAS mutation PCR-based testing procedure for rational individualized first-line-targeted therapy selection in metastatic colorectal cancer

KRAS mutation detection represents a crucial issue in metastatic colorectal cancer (mCRC). The optimization of KRAS mutation detection delay enabling rational prescription of first-line treatment in mCRC including anti-EGFR-targeted therapy requires robust and rapid molecular biology techniques. Rou...

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Bibliographic Details
Main Authors: Chretien, Anne-Sophie, Harlé, Alexandre, Meyer-Lefebvre, Magali, Rouyer, Marie, Husson, Marie, Ramacci, Carole, Harter, Valentin, Genin, Pascal, Leroux, Agnès, Merlin, Jean-Louis
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2013
Subjects:
Cancer Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797557/
https://ncbi.nlm.nih.gov/pubmed/24133623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.47
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