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IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis
Interleukin (IL)-32 is known to exert adujvant effects on innate immune response, however, receptors and downstream signaling pathways remain to be clarified. Here we found that IL-32γ upregulated serine protease activity of proteinase-3 (PR3), in turn triggering protease-activated receptor 2 (PAR2)...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3797434/ https://ncbi.nlm.nih.gov/pubmed/24129891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02960 |
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