Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha

INTRODUCTION: The present study assessed the potential functions of interleukin (IL)-32α on inflammatory arthritis and endotoxin shock models using IL-32α transgenic (Tg) mice. The potential signaling pathway for the IL-32-tumor necrosis factor (TNF)α axis was analyzed in vitro. METHODS: IL-32α Tg m...

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Main Authors: Nakayama, Masanori, Niki, Yasuo, Kawasaki, Toshiki, Takeda, Yuki, Horiuchi, Keisuke, Sasaki, Aya, Okada, Yasunori, Umezawa, Kazuo, Ikegami, Hiroyasu, Toyama, Yoshiaki, Miyamoto, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446501/
https://ncbi.nlm.nih.gov/pubmed/22613074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3850
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