Effects of the Deletion of Early Region 4 (E4) Open Reading Frame 1 (orf1), orf1-2, orf1-3 and orf1-4 on Virus-Host Cell Interaction, Transgene Expression, and Immunogenicity of Replicating Adenovirus HIV Vaccine Vectors

The global health burden engendered by human immunodeficiency virus (HIV)-induced acquired immunodeficiency syndrome (AIDS) is a sobering reminder of the pressing need for a preventative vaccine. In non-human primate models replicating adenovirus (Ad)-HIV/SIV recombinant vaccine vectors have been sh...

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Detalhes bibliográficos
Main Authors: Thomas, Michael A., Song, Rui, Demberg, Thorsten, Vargas-Inchaustegui, Diego A., Venzon, David, Robert-Guroff, Marjorie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797075/
https://ncbi.nlm.nih.gov/pubmed/24143187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076344
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