Improved PCR Performance Using Template DNA from Formalin-Fixed and Paraffin-Embedded Tissues by Overcoming PCR Inhibition

Formalin-fixed and paraffin-embedded (FFPE) tissues represent a valuable source for biomarker studies and clinical routine diagnostics. However, they suffer from degradation of nucleic acids due to the fixation process. Since genetic and epigenetic studies usually require PCR amplification, this deg...

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Autori principali: Dietrich, Dimo, Uhl, Barbara, Sailer, Verena, Holmes, Emily Eva, Jung, Maria, Meller, Sebastian, Kristiansen, Glen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796491/
https://ncbi.nlm.nih.gov/pubmed/24155973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077771
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