A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis

mir-17-92, a potent polycistronic oncomir, encodes six mature miRNAs with complex modes of interactions. In the Eμ-myc Burkitt’s lymphoma model, mir-17-92 exhibits potent oncogenic activity by repressing c-Myc-induced apoptosis, primarily through its miR-19 components. Surprisingly, mir-17-92 also e...

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Detalhes bibliográficos
Main Authors: Olive, Virginie, Sabio, Erich, Bennett, Margaux J, De Jong, Caitlin S, Biton, Anne, McGann, James C, Greaney, Samantha K, Sodir, Nicole M, Zhou, Alicia Y, Balakrishnan, Asha, Foth, Mona, Luftig, Micah A, Goga, Andrei, Speed, Terence P, Xuan, Zhenyu, Evan, Gerard I, Wan, Ying, Minella, Alex C, He, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796314/
https://ncbi.nlm.nih.gov/pubmed/24137534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00822
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