Redesigning secondary structure to invert coenzyme specificity in isopropylmalate dehydrogenase.
Rational engineering of enzymes involves introducing key amino acids guided by a knowledge of protein structure to effect a desirable change in function. To date, all successful attempts to change specificity have been limited to substituting individual amino acids within a protein fold. However, th...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37962/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8901552/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.22.12171 |
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