Redesigning secondary structure to invert coenzyme specificity in isopropylmalate dehydrogenase.

Rational engineering of enzymes involves introducing key amino acids guided by a knowledge of protein structure to effect a desirable change in function. To date, all successful attempts to change specificity have been limited to substituting individual amino acids within a protein fold. However, th...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Chen, R, Greer, A, Dean, A M
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1996
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37962/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8901552/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.22.12171
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