BRCA1 Targets G2/M Cell Cycle Proteins for Ubiquitination and Proteasomal Degradation

The BRCA1 tumor suppressor protein heterodimerizes with its partner protein, BARD1, via the RING domain present in both proteins. The heterodimer contains an E3 ubiquitin ligase activity and participates in multiple cellular functions such as cell cycle control, DNA repair and regulation of gene tra...

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Main Authors: Shabbeer, Shabana, Omer, Dorit, Berneman, Dana, Weitzman, Osnat, Alpaugh, Alexandra, Pietraszkiewicz, Alexandra, Metsuyanim, Sally, Shainskaya, Alla, Papa, Moshe Z., Yarden, Ronit I.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796024/
https://ncbi.nlm.nih.gov/pubmed/23246971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.522
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