EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas

Squamous cell carcinomas (SCCs) with an infiltrative invasion pattern carry a higher risk of treatment failure. Such infiltrative invasion may be mediated by a mesenchymal-like subpopulation of malignant cells that we have previously shown to arise from epithelial to mesenchymal transition (EMT) and...

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Main Authors: Basu, Devraj, Bewley, Arnaud F., Sperry, Steven M., Montone, Kathleen T., Gimotty, Phyllis A., Rasanen, Kati, Facompre, Nicole D., Weinstein, Gregory S., Nakagawa, Hiroshi, Diehl, J. Alan, Rustgi, Anil K., Herlyn, Meenhard
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796003/
https://ncbi.nlm.nih.gov/pubmed/23939378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1210
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