A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme.

To test whether the structure of a protein is determined in a manner akin to the assembly of a jigsaw puzzle, up to 10 adjacent residues within the core of T4 lysozyme were replaced by methionine. Such variants are active and fold cooperatively with progressively reduced stability. The structure of...

Full description

Saved in:
Bibliographic Details
Main Authors: Gassner, N C, Baase, W A, Matthews, B W
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC37959/
https://ncbi.nlm.nih.gov/pubmed/8901549
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items