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Clinical and MRI activity as determinants of sample size for pediatric multiple sclerosis trials
OBJECTIVE: To estimate sample sizes for pediatric multiple sclerosis (MS) trials using new T2 lesion count, annualized relapse rate (ARR), and time to first relapse (TTFR) endpoints. METHODS: Poisson and negative binomial models were fit to new T2 lesion and relapse count data, and negative binomial...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Lippincott Williams & Wilkins
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3795606/ https://ncbi.nlm.nih.gov/pubmed/23966255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182a6cb9b |
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