Clinical and MRI activity as determinants of sample size for pediatric multiple sclerosis trials

OBJECTIVE: To estimate sample sizes for pediatric multiple sclerosis (MS) trials using new T2 lesion count, annualized relapse rate (ARR), and time to first relapse (TTFR) endpoints. METHODS: Poisson and negative binomial models were fit to new T2 lesion and relapse count data, and negative binomial...

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Detalhes bibliográficos
Main Authors: Verhey, Leonard H., Signori, Alessio, Arnold, Douglas L., Bar-Or, Amit, Sadovnick, A. Dessa, Marrie, Ruth Ann, Banwell, Brenda, Sormani, Maria Pia
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795606/
https://ncbi.nlm.nih.gov/pubmed/23966255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182a6cb9b
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