HTRF analysis of soluble huntingtin in PHAROS PBMCs

OBJECTIVE: We measured the levels of mutant huntingtin (mtHtt) and total huntingtin (tHtt) in blood leukocytes from Prospective Huntington At-Risk Observational Study (PHAROS) subjects at 50% risk of carrying the Huntington disease mutation using a homogeneous time-resolved fluorescence (HTRF) assay...

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Main Authors: Moscovitch-Lopatin, Miriam, Goodman, Rachel E., Eberly, Shirley, Ritch, James J., Rosas, H. Diana, Matson, Samantha, Matson, Wayne, Oakes, David, Young, Anne B., Shoulson, Ira, Hersch, Steven M.
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795598/
https://ncbi.nlm.nih.gov/pubmed/23966247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182a55ede
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