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Biochemical and biophysical comparison of cleaved and uncleaved soluble, trimeric HIV-1 envelope glycoproteins

Human immunodeficiency virus type 1 (HIV-1) entry into host cells is mediated by the trimeric envelope glycoprotein complex (Env). Accordingly, the Env proteins are the targets for neutralizing antibodies (NAbs) and are the focus of vaccines intended to induce NAbs. Because the Env complex is labile...

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Main Authors: Dey, Antu K., David, Kathryn B., Lu, Min, Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795524/
https://ncbi.nlm.nih.gov/pubmed/19135223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.12.009
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