Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer

Background: Approximately 20% of all colorectal cancers are hypothesized to arise from the “serrated pathway” characterized by mutation in BRAF, high-level CpG Island Methylator Phenotype, and microsatellite instability/mismatch repair (MMR)-deficiency. MMR-deficient cancers show frequent losses of...

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Detalles Bibliográficos
Autores principales: Dawson, Heather, Koelzer, Viktor H., Lukesch, Anne C., Mallaev, Makhmudbek, Inderbitzin, Daniel, Lugli, Alessandro, Zlobec, Inti
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795344/
https://ncbi.nlm.nih.gov/pubmed/24130965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00265
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