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Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay
Migratory cells, including mammalian leukocytes and Dictyostelium, use G-protein-coupled receptor (GPCR) signaling to regulate MAPK/ERK, PI3K, TORC2/AKT, adenylyl cyclase and actin polymerization, which collectively direct chemotaxis. Upon ligand binding, mammalian GPCRs are phosphorylated at cytopl...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Company of Biologists
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3795335/ https://ncbi.nlm.nih.gov/pubmed/23902692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.122952 |
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