Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay

Migratory cells, including mammalian leukocytes and Dictyostelium, use G-protein-coupled receptor (GPCR) signaling to regulate MAPK/ERK, PI3K, TORC2/AKT, adenylyl cyclase and actin polymerization, which collectively direct chemotaxis. Upon ligand binding, mammalian GPCRs are phosphorylated at cytopl...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Brzostowski, Joseph A., Sawai, Satoshi, Rozov, Orr, Liao, Xin-hua, Imoto, Daisuke, Parent, Carole A., Kimmel, Alan R.
Format: Artigo
Langue:Inglês
Publié: The Company of Biologists 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795335/
https://ncbi.nlm.nih.gov/pubmed/23902692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.122952
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires