FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression

Elevated LDL-cholesterol is a risk factor for the development of cardiovascular disease. Thus, proper control of LDL-cholesterol homeostasis is critical for organismal health. Genetic analysis has identified PCSK9 (proprotein convertase subtilisin/kexin type 9) as a crucial gene in the regulation of...

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Autori principali: Tao, Rongya, Xiong, Xiwen, DePinho, Ronald A., Deng, Chu-Xia, Dong, X. Charlie
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795227/
https://ncbi.nlm.nih.gov/pubmed/23974119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.481473
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