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Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations

Enrichment analysis of gene sets is a popular approach that provides a functional interpretation of genome-wide expression data. Existing tests are affected by inter-gene correlations, resulting in a high Type I error. The most widely used test, Gene Set Enrichment Analysis, relies on computationall...

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Détails bibliographiques
Auteurs principaux: Yaari, Gur, Bolen, Christopher R., Thakar, Juilee, Kleinstein, Steven H.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794608/
https://ncbi.nlm.nih.gov/pubmed/23921631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt660
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