BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers

Here, we show for the first time, that the familial breast/ovarian cancer susceptibility gene BRCA1 activates the Notch pathway in breast cells by transcriptional upregulation of Notch ligands and receptors in both normal and cancer cells. We demonstrate through chromatin immunoprecipitation assays...

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Detalhes bibliográficos
Main Authors: Buckley, Niamh E., Nic An tSaoir, Caoimhe B., Blayney, Jaine K., Oram, Lisa C., Crawford, Nyree T., D’Costa, Zenobia C., Quinn, Jennifer E., Kennedy, Richard D., Harkin, D. Paul, Mullan, Paul B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794588/
https://ncbi.nlm.nih.gov/pubmed/23863842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt626
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