Fenofibrate Attenuated Glucose-Induced Mesangial Cells Proliferation and Extracellular Matrix Synthesis via PI3K/AKT and ERK1/2

Excess mesangial extracellular matrix (ECM) and mesangial cell proliferation is the major pathologic feature of diabetic nephropathy (DN). Fenofibrate, a PPARα agonist, has been shown to attenuate extracellular matrix formation in diabetic nephropathy. However, the mechanisms underlying this effect...

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Main Authors: Zeng, Rui, Xiong, Yan, Zhu, Fengming, Ma, Zufu, Liao, Wenhui, He, Yong, He, JinSeng, Li, Wei, Yang, Juan, Lu, Qian, Xu, Gang, Yao, Ying
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793917/
https://ncbi.nlm.nih.gov/pubmed/24130796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076836
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