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Repeated cocaine weakens GABA(B)-Girk signaling in Layer 5/6 pyramidal neurons in the prelimbic cortex
Repeated cocaine exposure triggers adaptations in Layer 5/6 glutamatergic neurons in the medial prefrontal cortex (mPFC) that promote behavioral sensitization and drug-seeking behavior. While suppression of metabotropic inhibitory signaling has been implicated in these behaviors, underlying mechanis...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3793643/ https://ncbi.nlm.nih.gov/pubmed/24094109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.07.019 |
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