Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D

Lipid aldehydes including isolevuglandins (IsoLGs) and 4-hydroxynonenal modify phosphatidylethanolamine (PE) to form proinflammatory and cytotoxic adducts. Therefore, cells may have evolved mechanisms to degrade and prevent accumulation of these potentially harmful compounds. To test if cells could...

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Bibliographische Detailangaben
Hauptverfasser: Guo, Lilu, Gragg, Stephen D., Chen, Zhongyi, Zhang, Yongqin, Amarnath, Venkataraman, Davies, Sean S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793619/
https://ncbi.nlm.nih.gov/pubmed/24018423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M042556
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