Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D

Lipid aldehydes including isolevuglandins (IsoLGs) and 4-hydroxynonenal modify phosphatidylethanolamine (PE) to form proinflammatory and cytotoxic adducts. Therefore, cells may have evolved mechanisms to degrade and prevent accumulation of these potentially harmful compounds. To test if cells could...

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Détails bibliographiques
Auteurs principaux: Guo, Lilu, Gragg, Stephen D., Chen, Zhongyi, Zhang, Yongqin, Amarnath, Venkataraman, Davies, Sean S.
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2013
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793619/
https://ncbi.nlm.nih.gov/pubmed/24018423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M042556
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