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Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D

Lipid aldehydes including isolevuglandins (IsoLGs) and 4-hydroxynonenal modify phosphatidylethanolamine (PE) to form proinflammatory and cytotoxic adducts. Therefore, cells may have evolved mechanisms to degrade and prevent accumulation of these potentially harmful compounds. To test if cells could...

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Autors principals: Guo, Lilu, Gragg, Stephen D., Chen, Zhongyi, Zhang, Yongqin, Amarnath, Venkataraman, Davies, Sean S.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793619/
https://ncbi.nlm.nih.gov/pubmed/24018423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M042556
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