Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D

Lipid aldehydes including isolevuglandins (IsoLGs) and 4-hydroxynonenal modify phosphatidylethanolamine (PE) to form proinflammatory and cytotoxic adducts. Therefore, cells may have evolved mechanisms to degrade and prevent accumulation of these potentially harmful compounds. To test if cells could...

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Bibliografiske detaljer
Main Authors: Guo, Lilu, Gragg, Stephen D., Chen, Zhongyi, Zhang, Yongqin, Amarnath, Venkataraman, Davies, Sean S.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2013
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793619/
https://ncbi.nlm.nih.gov/pubmed/24018423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M042556
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