Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D

Lipid aldehydes including isolevuglandins (IsoLGs) and 4-hydroxynonenal modify phosphatidylethanolamine (PE) to form proinflammatory and cytotoxic adducts. Therefore, cells may have evolved mechanisms to degrade and prevent accumulation of these potentially harmful compounds. To test if cells could...

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Autores principales: Guo, Lilu, Gragg, Stephen D., Chen, Zhongyi, Zhang, Yongqin, Amarnath, Venkataraman, Davies, Sean S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2013
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793619/
https://ncbi.nlm.nih.gov/pubmed/24018423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M042556
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