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Cholesterol lowering drug may influence cellular immune response by altering MHC II function
Major histocompatibility complex class II (MHC II) expressed on the surface of antigen-presenting cells (APCs) displays peptides to CD4(+) T cells. Depletion of membrane cholesterol from APCs by methyl β-cyclodextrin treatment compromises peptide-MHC II complex formation coupled with impaired bindin...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Biochemistry and Molecular Biology
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3793615/ https://ncbi.nlm.nih.gov/pubmed/24038316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M041954 |
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