Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation

Oxidized phospholipids (oxPLs) generated nonenzymatically display pleiotropic biological actions in inflammation. Their generation by cellular cyclooxygenases (COXs) is currently unknown. To determine whether platelets generate prostaglandin (PG)-containing oxPLs, then characterize their structures...

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Detalhes bibliográficos
Main Authors: Aldrovandi, Maceler, Hammond, Victoria J., Podmore, Helen, Hornshaw, Martin, Clark, Stephen R., Marnett, Lawrence J., Slatter, David A., Murphy, Robert C., Collins, Peter W., O'Donnell, Valerie B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793613/
https://ncbi.nlm.nih.gov/pubmed/23883581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M041533
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