Phospholipid-esterified Eicosanoids Are Generated in Agonist-activated Human Platelets and Enhance Tissue Factor-dependent Thrombin Generation

Here, a group of specific lipids, comprising phosphatidylethanolamine (PE)- or phosphatidylcholine (PC)-esterified 12S-hydroxyeicosatetraenoic acid (12S-HETE), generated by 12-lipoxygenase was identified and characterized. 12S-HETE-PE/PCs were formed within 5 min of activation by thrombin, ionophore...

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Detalhes bibliográficos
Main Authors: Thomas, Christopher P., Morgan, Lloyd T., Maskrey, Benjamin H., Murphy, Robert C., Kühn, Hartmut, Hazen, Stanley L., Goodall, Alison H., Hamali, Hassan A., Collins, Peter W., O'Donnell, Valerie B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844139/
https://ncbi.nlm.nih.gov/pubmed/20061396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078428
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