Thrombin induces epithelial-mesenchymal transition via PAR-1, PKC, and ERK1/2 pathways in A549 cells

Thrombin activates protease-activated receptor (PAR)-1 and induces a myofibroblast phenotype in normal lung fibroblasts. The origins of myofibroblasts are resident fibroblasts, fibrocytes, and epithelial-mesenchymal transition (EMT). We investigated the effects of thrombin, an important mediator of...

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Detalhes bibliográficos
Main Authors: Song, Jeong Sup, Kang, Chun Mi, Park, Chan Kwon, Yoon, Hyung Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: Informa Healthcare 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793269/
https://ncbi.nlm.nih.gov/pubmed/23919450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/01902148.2013.820809
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