Structure of fully liganded Hb ζ(2)β(2) (s) trapped in a tense conformation

A variant Hb ζ(2)β(2) (s) that is formed from sickle hemoglobin (Hb S; α(2)β(2) (s)) by exchanging adult α-globin with embryonic ζ-globin subunits shows promise as a therapeutic agent for sickle-cell disease (SCD). Hb ζ(2)β(2) (s) inhibits the polymerization of deoxy­genated Hb S in vitro and revers...

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Bibliografiske detaljer
Main Authors: Safo, Martin K., Ko, Tzu-Ping, Abdulmalik, Osheiza, He, Zhenning, Wang, Andrew H.-J., Schreiter, Eric R., Russell, J. Eric
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2013
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792644/
https://ncbi.nlm.nih.gov/pubmed/24100324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444913019197
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