Mechanistic insights into CED-4-mediated activation of CED-3

Programmed cell death in Caenorhabditis elegans requires activation of the caspase CED-3, which strictly depends on CED-4. CED-4 forms an octameric apoptosome, which binds the CED-3 zymogen and facilitates its autocatalytic maturation. Despite recent advances, major questions remain unanswered. Impo...

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Autori principali: Huang, Weijiao, Jiang, Tianyu, Choi, Wooyoung, Qi, Shiqian, Pang, Yuxuan, Hu, Qi, Xu, Yanhui, Gong, Xinqi, Jeffrey, Philip D., Wang, Jiawei, Shi, Yigong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2013
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792479/
https://ncbi.nlm.nih.gov/pubmed/24065769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.224428.113
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