The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

Oncogenic stimuli trigger the DNA damage response (DDR) and induction of the alternative reading frame (ARF) tumor suppressor, both of which can activate the p53 pathway and provide intrinsic barriers to tumor progression. However, the respective timeframes and signal thresholds for ARF induction an...

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Detalhes bibliográficos
Main Authors: Evangelou, K, Bartkova, J, Kotsinas, A, Pateras, I S, Liontos, M, Velimezi, G, Kosar, M, Liloglou, T, Trougakos, I P, Dyrskjot, L, Andersen, C L, Papaioannou, M, Drosos, Y, Papafotiou, G, Hodny, Z, Sosa-Pineda, B, Wu, X-R, Klinakis, A, Ørntoft, T, Lukas, J, Bartek, J, Gorgoulis, V G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792440/
https://ncbi.nlm.nih.gov/pubmed/23852374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.76
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