ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence

Werner syndrome (WS) results from dysfunction of the WRN protein, and is associated with premature aging and early death. Here we report that loss of WRN function elicits accumulation of the Yes-associated protein (YAP protein), a major effector of the Hippo tumor suppressor pathway, both experiment...

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Main Authors: Fausti, F, Di Agostino, S, Cioce, M, Bielli, P, Sette, C, Pandolfi, P P, Oren, M, Sudol, M, Strano, S, Blandino, G
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2013
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Original Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792425/
https://ncbi.nlm.nih.gov/pubmed/23933816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.101
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