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Skewed X-Chromosome Inactivation Is Associated with Trisomy in Women Ascertained on the Basis of Recurrent Spontaneous Abortion or Chromosomally Abnormal Pregnancies

An increase in extremely skewed X-chromosome inactivation (XCI) (⩾90%) among women who experienced recurrent spontaneous abortion (RSA) has been previously reported. To further delineate the etiology of this association, we have evaluated XCI status in 207 women who experience RSA. A significant exc...

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Auteurs principaux: Beever, C. L., Stephenson, M. D., Peñaherrera, M. S., Jiang, R. H., Kalousek, D. K., Hayden, M., Field, L., Brown, C. J., Robinson, W. P.
Format: Artigo
Langue:Inglês
Publié: The American Society of Human Genetics 2003
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC379232/
https://ncbi.nlm.nih.gov/pubmed/12497247
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