Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9)-tetrahydrocannabivarin (THCV), to produce CB(1) receptor inverse agonism symptoms of nausea in rats

BACKGROUND AND PURPOSE: The cannabinoid 1 (CB(1)) receptor inverse agonists/antagonists, rimonabant (SR141716, SR) and AM251, produce nausea and potentiate toxin-induced nausea by inverse agonism (rather than antagonism) of the CB(1) receptor. Here, we evaluated two phytocannabinoids, cannabidivarin...

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Detalhes bibliográficos
Main Authors: Rock, Erin M, Sticht, Martin A, Duncan, Marnie, Stott, Colin, Parker, Linda A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792004/
https://ncbi.nlm.nih.gov/pubmed/23902479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12322
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