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Levels of heroin and its metabolites in blood and brain extracellular fluid after i.v. heroin administration to freely moving rats
BACKGROUND AND PURPOSE: Heroin, with low affinity for μ-opioid receptors, has been considered to act as a prodrug. In order to study the pharmacokinetics of heroin and its active metabolites after i.v. administration, we gave a bolus injection of heroin to rats and measured the concentration of hero...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Publishing Ltd
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3791993/ https://ncbi.nlm.nih.gov/pubmed/23865556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12305 |
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