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Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains
Aberrant protein aggregation is a dominant pathological feature in neurodegenerative diseases. Protein aggregates cannot be processed by the proteasome; instead, they are frequently concentrated to a perinuclear inclusion body, the aggresome, and subsequently removed by autophagy. Paradoxically, pro...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3791850/ https://ncbi.nlm.nih.gov/pubmed/24035499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.08.016 |
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