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Excess Podocyte Semaphorin-3A Leads to Glomerular Disease Involving PlexinA(1)–Nephrin Interaction
Semaphorin-3A (Sema3a), a guidance protein secreted by podocytes, is essential for normal kidney patterning and glomerular filtration barrier development. Here, we report that podocyte-specific Sema3a gain-of-function in adult mice leads to proteinuric glomerular disease involving the three layers o...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3791681/ https://ncbi.nlm.nih.gov/pubmed/23954273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.06.022 |
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