Excess Podocyte Semaphorin-3A Leads to Glomerular Disease Involving PlexinA(1)–Nephrin Interaction

Semaphorin-3A (Sema3a), a guidance protein secreted by podocytes, is essential for normal kidney patterning and glomerular filtration barrier development. Here, we report that podocyte-specific Sema3a gain-of-function in adult mice leads to proteinuric glomerular disease involving the three layers o...

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Autores principales: Reidy, Kimberly J., Aggarwal, Pardeep K., Jimenez, Juan J., Thomas, David B., Veron, Delma, Tufro, Alda
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2013
Materias:
Regular Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791681/
https://ncbi.nlm.nih.gov/pubmed/23954273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.06.022
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