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Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy

The use of paclitaxel (Taxol®), a microtubule stabilizer, for cancer treatment is often limited by its associated peripheral neuropathy (chemotherapy-induced peripheral neuropathy, CIPN) which predominantly results in sensory dysfunction including chronic pain. Here we show that paclitaxel CIPN was...

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Detalhes bibliográficos
Main Authors: Zhang, Haijun, Boyette-Davis, Jessica A., Kosturakis, Alyssa K., Li, Yan, Yoon, Seo-Yeon, Walters, Edgar T., Dougherty, Patrick M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791166/
https://ncbi.nlm.nih.gov/pubmed/23726937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2013.03.012
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